Amnestic Mild Cognitive Impairment Parkinson’s disease

Amnestic mild cognitive impairment in PD, white matter structural changes and mechanisms.

Mild cognitive impairment (MCI) is a heterogeneous cognitive disorder that is often comorbid with Parkinson’s diseases (PD). The amnestic subtype of PD-MCI (PD-aMCI) has a higher risk to develop dementia. However, there is a lack of studies on the white matter (WM) structural changes of PD-aMCI.

DTI measure differences between PD-CN and normal controls.

Compared to normal controls, PD-CN showed significantly higher voxel-based DTI values in the caudate. The color bar indicates the 1-p value ranging from 0.95 to 1. Higher axial diffusivity values A) and radial diffusivity values B) in PD-CN were shown on the axial slices ranging from -2 mm to 18 mm at z-axis, with an interval of 4 mm (from bottom to top).