Low Frequency BOLD resting-state fMRI are Decreased in AD

Spontaneous low frequency BOLD signal variations from resting-state fMRI 

are decreased in Alzheimer disease

Brain activity and glucose metabolism maps.

MNI-152 T1-weighted anatomical images in coronal, sagittal, and axial orientations (A, B). Corresponding FDG-PET SUVR images of glucose metabolism from a healthy elderly subject, and healthy elderly group averaged (C, G); a patient with Alzheimer disease, and Alzheimer disease group averaged (D, H). Brain activity maps obtained using RS-fMRI in the same healthy elderly subject, and healthy elderly group averaged (E, I) and patient with Alzheimer disease, and Alzheimer disease group averaged (F, J).

Regional brain activity

The average brain activity measured by RS-fMRI in NEC and Alzheimer disease subjects in the cerebellum, amygdala, thalamus, accumbens, caudate, pallidum, hippocampus, and putamen. The error bars represent the standard error of the mean and asterisks show significant differences between groups