(A) Neurofilament light (NFL) and tau levels are significantly correlated. NFL correlates positively with (B) disease burden and (C) 5-year probability of disease onset but negatively with (D) total functional capacity. Premanifest gene expansion carrier • Manifest Huntington’s disease.
Correlations between tau and disease progression in Huntington’s disease.
Tau does not correlate with (A) 5-year probability of disease onset but correlations with (B) disease burden, (C) total functional capacity, and (D) total motor score were significant. ○ Premanifest gene expansion carrier • Manifest Huntington’s disease.
Neurofilament light (NFL) has stronger correlations with clinical scores like (A) stroop interferens, and (B) category fluency, compared with (C and D) tau. ○ Premanifest gene expansion carrier • Manifest Huntington’s disease.
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