Grey & WM Changes across the ALS-FDC

Unique grey matter atrophy across patient groups

Voxel-based morphometry analysis showing regions of unique brain atrophy across groups. Clusters are overlaid on the MNI standard brain (t = 2.41). Colored voxels show regions that were significant in the analyses for p<0.05 FWE corrected. 

Overlap grey matter atrophy across patient groups

Voxel-based morphometry analysis showing region of brain atrophy overlap; i) and ii) show sagittal and coronal views of the anterior cingulate atrophy cluster; iii) and iv) show sagittal and coronal views of the motor cortex atrophy cluster. Clusters are overlaid on the MNI standard brain (t = 2.41).   

Unique white matter changes across patient groups

Diffusion tensor imaging analysis showing regions of unique white matter changes across groups. Clusters are overlaid on the MNI standard brain (t = 2.41). Colored voxels show regions that were significant in the analyses for p<0.05 FWE corrected

Overlap white matter changes across patient groups

Main grey matter regions & their underlying white matter tracts across patient groups. Shading of text boxes indicates severity of impairment based on the imaging findings with lighter boxes indicating higher impairment & darker boxes indicated lesser impairment. CST = corticospinal tract; MPFC = medial prefrontal cortex; CC = corpus callosum; ILF = inferior longitudinal fasciculus