Saturday, June 20, 2020

Network Plasticity following Brain Injury

https://ndownloader.figstatic.com/files/432525/preview/432525/preview.jpg
MR images of TBI. 

Axial MR images providing examples of the types of discrete frontal lesions occurring in this sample. Examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI)
Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased “small-worldness” from 3 months to 6 months post injury. 

Cumulative degree distributions

The group averaged cumulative degree distributions  from (a) TBI at Time 1 and (b) Time 2 on double logarithmic scale. The solid curves are the best fitting stretched exponential function  to the averaged cumulative degree distributions ranging from degree k = 30 to 80. The value of fitting parameter  was 3.65±0.41 for TBI at Time 1 and 4.58±0.18 for Time 2, respectively. For Control group, the value of  was 4.78±0.16.

Results here indicate that recovery from TBI is associated with three important changes in resting networks: 1) a reduction in the number of highly significant connections in the overall network (strength S), or reduced “cost”, but little to no change in the number of connections, or sparsity; 2) a transition of the degree distribution from a power law with exponential decay at three months post injury to a stretched exponential decay at six months post injury; 3) increasing “small-worldness” during recovery, but residually diminished small-worldness compared to the HC sample. 


No comments:

Post a Comment

BStem CSA: Microstructural Cerebral Damage w/Cerebral Microangiopathy

DTI changes of CSA-CSR patients were most prominent in the brainstem.  Subtle microstructural changes in the brainstem might be a neuroanato...