Regional gray matter (GM) atrophy in myotonic dystrophy type 1 (DM1) patients compared with controls
Clusters of reduced GM volume in DM1 patients compared with controls (clusters significant at p <0.05, FWE corrected, extended threshold = 49 voxels). The colored bar represents the T score. Clusters are diffuse in both hemispheres, particularly in the orbitofrontal, medial frontal, precentral, anterior insula, posterior cingulate, superior temporal, hippocampal, parahippocampal, fusiform, and lingual areas. Clusters are also found bilaterally in subcortical areas, including the thalamus, caudate nucleus, and putamen.
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