(A) Neurofilament light (NFL) and tau levels are significantly correlated. NFL correlates positively with (B) disease burden and (C) 5-year probability of disease onset but negatively with (D) total functional capacity. ○ Premanifest gene expansion carrier • Manifest Huntington’s disease.
Correlations between tau and disease progression in Huntington’s disease.
Tau does not correlate with (A) 5-year probalility of disease onset but correlations with (B) disease burden, (C) total functional capacity, and (D) total motor score were significant. ○ Premanifest gene expansion carrier • Manifest Huntington’s disease.
Comparing the correlations of neurofilament light and tau with cognitive test scores.
Neurofilament light (NFL) has stronger correlations with clinical scores like (A) stroop interferens, and (B) category fluency, compared with (C and D) tau. ○ Premanifest gene expansion carrier • Manifest Huntington’s disease.
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