Friday, June 19, 2020

Anatomical & Functional Deficits in Patients with Amnestic Mild Cognitive Impairment


VBM analysis revealed decreased gray matter volume in MCI group compared to controls

Compared to the control group, the MCI group showed significantly decreased GMV (blue region) in mainly in bilateral prefrontal, left temporal and posterior cingulate cortex.

ALFF analysis revealed regional functional alteration in MCI group compared to controls.

Compared to the control group, both increased and decreased regional function was revealed in MCI group in relative to controls.

Overlap between the morphometric (red regions) and functional (blue regions) results.

Though the decreased ALFF in the right middle frontal gyrus and left inferior frontal gyrus (Within red circle) were found quite near the decreased GMV in the same region, the ALFF in these regions did not correlate with the GMV. 

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