Fig 1 depicts a relatively small cortical lesion followed over all 12 time-points. The CL was scored by consensus (conL) in the first 6 TP (white arrow). From TP 7 to TP 12 (dotted white arrows), the specific CL was no longer detected by both of the raters consensually (non-consenus lesion).
Overview of different CL types in distinct brain anatomical brain regions.
Fig 2 displays different cortical lesion types in various anatomical brain regions marked by white arrows. Lesions appeared with varying volumes and signal intensities differed between distinct CLs.
Differences of mean cortical lesion volumes and mean signal intensities between conL and non-consensus lesions
Boxplots in fig 3 display the mean lesion volume (in mm3) and mean signal intensities of CLs that were detected by only one of the two raters (non-conL; left side) vs. CLs that were detected by both raters (conL; right side). Mean volumes and mean relative signal intensities of conL were significantly higher (p<0.05) compared to non-conL. Slightly less than a half of the CL were considered as reliably detectable on longitudinal DIR images. Lesions that were not reliably identifiable by both raters seem to be characterized by lower signal intensity and smaller size, or located in distinct anatomical brain regions.
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