Posteromedial Cortex Deactivation MCI/AD

Postero-medical cortex (PMC), denoted in red and overlaid on a canonical T1-weighted brain template image in three orthogonal views,

 was used as an apriori functional region of interest.

In this region parameter estimates for activation magnitude showed a lesser-to-greater activation from Control, to MCI, to AD subjects.Comparable values in AD higher percentage.

Bar graph demonstrates the proportion of activators and deactivators among the four diagnostic groups.

The proportion of deactivators was significantly different (p<0.05) across diagnostic groups after adjusting for age, education and baseline MMSE score, with significantly fewer deactivators with increasing cognitive impairment grouping

Bar graph demonstrates activation magnitude parameter estimate in the PMC region (Fig 1), demonstrating a continuum from control, to MCI-Nonconverter, to MCI-Converter, to AD.

There were statistically significant (p<0.05) differences between all groups with the exception of the control and MCI-Nonconverter group, and the AD and MCI-Converter group. Note the overall pattern of negative activation magnitude in the Control and MCI-Nonconverter groups, and positive activation magnitude in the AD and MCI-Converter groups. Activation in AD more clearly defined and clear active in all regions.