Seizures (SANAD)

Residual plots and incorporation of time-dependent covariate effects were used to investigate the proportional hazards assumption. The predictive accuracy of the models was assessed using the c-statistic. Analyses were performed using R version 3.2.3, and significance was set at the 5% level. Computer code for all analyses

1593 participants included in this analysis, 536 had a first breakthrough seizure with median time to first breakthrough seizure 0.7 years from starting treatment (interquartile range (IQR) 0.2–1.2 years). Additionally, the median follow-up time from achievement of remission to date of last follow-up was\(IQR 1.0–3.3 years).