CADP patients exhibiting BBBd at the time of first diagnosis failed in more neuropsychological tests than patients with intact integrity of the BBB (p < 0.05). When compared directly with the HC group, CADP patients performed worse than HC in tests measuring information processing ability and speed as well as phonemic verbal fluency after adjusting for confounding covariates.
The results of the CSF analysis of one of the patients were not available. Eight from the remaining 15 CADP patients (53%) exhibited BBBd at the time of first CADP diagnosis (mean range between CSF analysis and current neuropsychological testing 4.1 years, SD 3.1 years) but none exhibited CSF pleocytosis or immunoglobulin synthesis. Artificial blood contamination of the CSF was present in only two patients: one patient had only 1 erythrocyte/μl and a dysfunctional BBB, while another had 132 erythrocytes/μl and an intact BBB.
Just as a note, due to positive current events, these postings will be infrequent for the time being. Looking forward to a semi regular schedule in the near future.
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